Everything You Should Know About GW1516, GW501516, Cardarine and Compound 14

Everything You Should Know About GW1516, GW501516, Cardarine and Compound 14

If you're keeping up with the news, you may have noticed some renewed interest in a chemical frequently referred to as "516". Despite the drug first emerging in 2001, being classified unfit for human testing or consumption in 2007, and being banned by the World Anti-Doping Agency in 2009, it continues to show up periodically in journalism. Sometimes described as the "exercise pills" of the future.

At Weight Crafters, we have always sought to help people.

Most commonly, our weight loss camp clients need help losing a significant amount of weight in a relatively short time frame.

The reasons vary - some clients come to us after being told by their doctor that their health is in peril as a result of their BFP & BMI and lack of activity. Others are seeing the early signs of diabetes, HBP, Osteoperosis and Athritis and know they need to do something to prevent the rapid decline of their health. Some seek out a fat camp or fat farm solution to attend because their families are concerned. And some of our clients show up to get a solid fitness vacation in, tighten up and restart their fitness regiment

Regardless of their reasons and motivations for spending time with us, at Weight Crafters we do the best we can to help them get healthy - and stay healthy.

What is the connection between our approach vs that of the marketed exercise pills?

Simple: Exercise pills have proven to be dangerous and are at best, under-researched in clinical, time tested trials.

Quick fixes almost always lead to Long term brokeness when it comes to health.


The Attraction to Exercise Pills

There are two particularly common chemicals being sold under false pretense and abused today as exercise pills. The newest is Compound 14, and the most hyped is GW-501516 (also referred to as Enduborol, Cardarine, GW1516 or simply 516).

Under normal conditions, our bodies burn glucose for energy whenever possible. When under stress (intense exercise for example) the body will also burn stored fat to maintain energy levels and keep the brain functioning properly.

GW-501516 is an activator of PPAR-delta (Peroxisome Proliferator Activator Receptors). When forced on, these receptors in the body trigger the fat burning process regardless of the availability of glucose. It's a lot like placing your finger over the sensor on an automatic night-light, forcing it to stay on.

Compound 14 works a little differently. It inhibits the function of an enzyme in the body called ATIC, responsible for the insulin signaling process. This essentially tells the body that energy is running low, and more glucose needs to be burned asap.

Both chemicals trick the body into burning more stored or available energy, similar to the way it would during an intense exercise session. GW-501516 in particular, targets fat directly.

What does this mean for potential consumers looking to lose weight? If story spinners are to be believed, it means that you can finally get all the benefits of a vigorous workout without ever leaving your couch.


What's the Catch?

Although there are several marketed and inflated promises about the potential benefits of these chemicals, there are some very serious potential drawbacks.

Compound 14 is new, very experimental, not time tested and lacks proper packaging for human consumption.

Compound 14 appears to have a relatively natural interaction with cells in the body, helping obese subjects to burn energy more quickly. It has been tested on mice in a lab and shown to reduce weight significantly in obese mice while having little or no effect on normally sized mice.

While this research does sounds good on the surface, much further testing is required - and human tests have not even begun. We cannot begin to guess what side effects may be found for long term usage, over usage or even just simple Human usage of the drug.

Furthermore, since compound 14 is still in the early stages of development and testing, the idea that secondary non regulated manufacturers have already developed a pill and labeled it proper for human consumption is alarming. During the last published tests with mice, the compound was directly injected. Regulated Drug manufacturers would have to scientifically engineer a proper formula to get compound 14 through the digestive system and into the bloodstream, assuming they can demonstrate safe and efffective human trials and then package it properly in the first place.

In short - if you're buying "compound 14 pills" from someone somewhere, it's probably not compound 14 at worse and it is not human tested in medical environment at best. So, you're gambling with your health and perhaps your life on an untested drug.

CW-501516 (Cardarine, Endurobol, CW1516, or 516) causes cancer in lab animals.

Some journalists covering 516 have mentioned it, but the majority marginalize the results - or leave this part out completely.

GW-501516 first showed up in research around 2001, and was intended for use controlling cholesterol in diabetics. Because it causes the body to burn fat directly, it very quickly began to sound like the perfect "miracle cure" for obesity.

But then in 2007, longer-term research studies were released that proved it was causing rapid, aggressive cancer development in test animals. The pharmaceutical company responsible for developing 516 promptly shelved it, and it remains highly unlikely that it will ever be tested on humans - in a laboratory.

On the street? That's a different story.

Following the viral story of a drug that actually burns fat, secondary, unregulated market manufacturers quickly began producing 516 and selling it illicitly. Often listed as a "laboratory chemical" for "experimental use only" and specifically labeled "not for human consumption", these peddlers have been making a killing on 516 ever since. If you'll pardon the pun. For about $1,000, athletes can get a 10-gram supply of the stuff from off the book sources - and they frequently do.

This phenomenon is made worse by a stream of articles and posts sharing weight loss success stories, even though there is no way to confirm the validity of such claims.

In June of 2018, the Therapeutic Goods Administration in Australia (TGA) included GW1516 in the Poisons Standard under Schedule 10. This places it among substances of such danger to health as to warrant the prohibition of sale, supply and use.  It has never been approved for human consumption anywhere in the world, due to its carcinogenic properties. And yet, athletes continue to test positive for it.

Will a safe exercise pill ever truly arrive?

Perhaps. Many scientists and researchers are dedicating vast time and resources to make it a reality. Some hope to short-circuit the body's fat burning system like 516 does. Some hope to enhance the genes responsible for increased risk of obesity. Some hope to change how the body stores fat in the first place.

Until a legitimate supplement or drug arrives on the market that has passed thorough testing and due diligence however, it is best to steer clear.


If exercise pills aren't an option, what can I do?

Get up, get out, and get moving! Residential weight loss programs, fitness camps and fat farms have been around for decades - but they always rely on a combination of healthy diet and plenty of exercise / activity to get results.

That's because regular exercise provides powerful health benefits beyond just burning fat. It can improve your skin tone, reduce your risk of leading killers like heart disease, stroke and diabetes, and decrease your risk of injuries later in life.

Exercise has been shown to reduce the risks of debilitating falls in the elderly, as well as the risk of mental illness. It provides powerful anti-depressant effects. It strengthens your bone density. It improves your lung capacity and helps to heal the effects of long-term smoking.

Good old-fashioned exercise provides a seemingly endless list of positive rewards. Would you really sacrifice all of that in exchange for a pill that will most likely give you cancer?

We hope not.

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